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Pantaprazole 40 mg + Domperidone 30 mg SR Capsules
Pantaprazole 40 mg A proton pump inhibitor, Benzimidazole derivative, Anti-ulcer. Mechanism of Action of Pantoprazole is a proton pump inhibitor. It is a prodrug. After administration, it diffuses into the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Pantoprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Pantoprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Pantoprazole is more acid stable and its activity is lowered in higher pH. It is the only proton pump inhibitor which is available in parenteral form.
Domperidone:
Antidopaminergic, Motility stimulant, Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of domperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces the Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitate gastric emptying. Domperidone is used in a migraine to relieve nausea and vomiting.
Anaesthetic adjuncts:
It is used preoperatively in order to reduce the postoperative vomiting.